Assay testing procedure of ferric pyrophosphate by titration method
Assay (By Titration Method) of ferric pyrophosphate
Dissolve about 0.5 to 1.0 g of sample in 40 ml of distilled water in an iodine flask. Add 20 ml of concentrated hydrochloric acid. Mix, add 3 g of potassium iodide and then allow to stand for 5 min. Titrate the liberated iodine with standardized 0.1 M sodium thiosulfate, using starch solution as indicator to the end point disappearance of blue color produced by starch solution. Avoid vigorous mixing during the titration.
Perform a blank in a similar manner, omitting the sample.
(T1-T2) × M × 0.05585 × 100
Fe (%) = ---------------------------------------
W
Fe (%) × 745.21
FPP (%) = ---------------------------
55.85
Where
T1 = sample titre in ml
T2 = blank titre in ml
0.05585 = atomic weight of iron × 10-3
745.21 = molecular weight of ferric pyro phosphate.
55.85 = molecular weight of Iron.
M = molarity of sodium thiosulfate.
W = sample weight (g)
Limit: Not less than 99.00 % (w/w)
Preparation of 0.1 M Sodium thiosulfate:
Weigh accurately 25 g of sodium thiosulphate and 0.2 g sodium carbonate, dissolve in water and make up to 1 L in water.
Standardization of 0.1 M Sodium thiosulfate:
Weight two replicated of 40 mg of potassium dichromate and add 5 ml of concentrated hydrochloric acid, then dissolve. Then add 50 ml of water. Add 1 ml of starch solution then titrate with 0.1 M Sodium Thiosulphate to disappear the blue color produced by starch solution.
M = Weight of potassium dichromate/49.04×Titer Value.
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